Article
Quantitative prediction of conditional vulnerabilities in regulatory and metabolic networks using PRIME.
NPJ systems biology and applications - 6 Dec 2021
Immanuel Selva Rupa Christinal, Arrieta-Ortiz Mario L, Ruiz Rene A, Pan Min, Lopez Garcia de Lomana Adrian, Peterson Eliza J R, Baliga Nitin S
Abstract excerpt
The ability of Mycobacterium tuberculosis (Mtb) to adopt heterogeneous physiological states underlies its success in evading the immune system and tolerating antibiotic killing. Drug tolerant phenotypes are a major reason why the tuberculosis (TB) mortality rate is so high, with over 1.8 million deaths annually. To develop new TB therapeutics that better treat the infection (faster and more completely), a...
Topics
- Humans
- Metabolic Networks and Pathways
- Mycobacterium tuberculosis
- Phenotype
- Tuberculosis