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Article

Age-associated genes in human mammary gland drive human breast cancer progression

15 Jun 2020

Abstract excerpt

BACKGROUND: Aging is a comorbidity of breast cancer suggesting that aging-associated transcriptome changes may promote breast cancer progression. However, the mechanism underlying the age effect on breast cancer remains poorly understood. METHOD: We analyzed transcriptomics of the matched normal breast tissues from the 82 breast cancer patients in The Cancer Genome Atlas (TCGA) dataset with linear regression for...

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PMID: 32539762
DOI: 10.1186/s13058-020-01299-2

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