A novel age-related gene expression signature associates with proliferation and disease progression in breast cancer

Abstract excerpt

BACKGROUND AND OBJECTIVE: Breast cancer (BC) diagnosed at ages <40 years presents with more aggressive tumour phenotypes and poorer clinical outcome compared to older BC patients. Here, we explored transcriptional BC alterations to gain a better understanding of age-related tumour biology, also subtype-stratified. METHODS: We studied publicly available global BC mRNA expression (n = 3999) and proteomics data...

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