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Article

Metabolic changes associated with adaptive resistance to daptomycin in Streptococcus mitis-oralis.

BMC microbiology - 15 Jun 2020

Parrett Allison, Reed Joseph M, Gardner Stewart G, Mishra Nagendra N, Bayer Arnold S, Powers Robert, Somerville Greg A

Abstract excerpt

BACKGROUND: Viridans group streptococci of the Streptococcus mitis-oralis subgroup are important endovascular pathogens. They can rapidly develop high-level and durable non-susceptibility to daptomycin both in vitro and in vivo upon exposure to daptomycin. Two consistent genetic adaptations associated with this phenotype (i.e., mutations in cdsA and pgsA) lead to the depletion of the phospholipids,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32539684
DOI: 10.1186/s12866-020-01849-w
PMCID: PMC7296729

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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