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Metabolic Mitigation of Staphylococcus aureus Vancomycin Intermediate-Level Susceptibility

6 Nov 2017

Abstract excerpt

ABSTRACT Staphylococcus aureus is a major human pathogen whose infections are increasingly difficult to treat due to increased antibiotic resistance, including resistance to vancomycin. Vancomycin-intermediate S. aureus (VISA) strains develop resistance to vancomycin through adaptive changes that are incompletely understood. Central to this adaptation are metabolic changes that permit growth in the presence of...

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PMID: 29109158
DOI: 10.1128/aac.01608-17

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