Article
Wnt activation by wild type and mutant myocilin in cultured human trabecular meshwork cells.
PloS one - 1 Jan 2012
Shen Xiang, Ying Hongyu, Yue Beatrice Y J T
Abstract excerpt
BACKGROUND: Myocilin is a gene linked to the most prevalent form of glaucoma, a major blinding disease. The trabecular meshwork (TM), a specialized eye tissue, is believed to be involved, at least in part, in the development of glaucoma. The Pro³⁷⁰ to Leu (P370L) mutation of myocilin is associated with severe glaucoma phenotypes and Gln³⁶⁸ stop (Q368X) is the most common myocilin mutation reported. Myocilin, upon...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.