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Article

Suppression of TGF-β1 signaling by Matrigel via FAK signaling in cultured human trabecular meshwork cells.

Scientific reports - 1 Apr 2021

Zhang Yuan, Tseng Scheffer C G, Zhu Ying-Ting

Abstract excerpt

The trabecular meshwork (TM) is composed of TM cells and beams of the extracellular matrix, together contributing to aqueous humor (AH) outflow resistance. Herein, we validated that our culture system on 2D Matrigel expressed putative TM markers and myocilin, of which the latter was upregulated by dexamethasone. Continuous passage of these cells on 2D Matrigel resulted in a gradual loss of expression of these...

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Identifiers

PMID: 33795740
DOI: 10.1038/s41598-021-86591-7
PMCID: PMC8016910

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