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Article

Existence of the Canonical Wnt Signaling Pathway in the Human Trabecular Meshwork

7 Sept 2012

Abstract excerpt

PURPOSE: We previously discovered elevated levels of secreted frizzled-related protein 1 (sFRP1), the Wnt signaling pathway inhibitor, in the glaucomatous trabecular meshwork (GTM), and found that key canonical Wnt signaling pathway genes are expressed in the trabecular meshwork (TM). The purpose of our study was to determine whether a functional canonical Wnt signaling pathway exists in the human TM (HTM)....

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Share to Glaucoma and retinal disorders
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PMID: 22956608
DOI: 10.1167/iovs.12-9664

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