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Article

Flavonoids improve the stability and function of P23H rhodopsin slowing down the progression of retinitis pigmentosa in mice.

Journal of neuroscience research - 1 Apr 2022

Ortega Joseph Thomas, Parmar Tanu, Carmena-Bargueño Miguel, Pérez-Sánchez Horacio, Jastrzebska Beata

Abstract excerpt

The balanced homeostasis of the G protein-coupled receptor (GPCR), rhodopsin (Rho), is required for vision. Misfolding mutations in Rho cause photoreceptor death, leading to retinitis pigmentosa (RP) and consequently blindness. With no cure currently available, the development of efficient therapy for RP is an urgent need. Pharmacological supplementation with molecular chaperones, including flavonoids, improves...

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Identifiers

PMID: 35165923
DOI: 10.1002/jnr.25021
PMCID: PMC9615108

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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