Deep DNA sequencing of MGMT, TP53 and AGT in Mexican astrocytoma patients identifies an excess of genetic variants in women and a predictive biomarker.

doi:10.1007/s11060-022-04214-1

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Article

Deep DNA sequencing of MGMT, TP53 and AGT in Mexican astrocytoma patients identifies an excess of genetic variants in women and a predictive biomarker.

Journal of neuro-oncology - 1 Jan 2023

Carlos-Escalante José Alberto, Mejía-Pérez Sonia Iliana, Soto-Reyes Ernesto, Guerra-Calderas Lissania, Cacho-Díaz Bernardo, Torres-Arciga Karla, Montalvo-Casimiro Michel, González-Barrios Rodrigo, Reynoso-Noverón Nancy, Ruiz-de la Cruz Miguel, Díaz-Velásquez Clara Estela, Vidal-Millán Silvia, Álvarez-Gómez Rosa María, Sánchez-Correa Thalía Estefanía, Pech-Cervantes Claudio Hiram, Soria-Lucio José Antonio, Pérez-Castillo Areli, Salazar Ana María, Arriaga-Canon Cristian, Vaca-Paniagua Felipe, González-Arenas Aliesha, Ostrosky-Wegman Patricia, Mohar-Betancourt Alejandro, Herrera Luis A, Corona Teresa, Wegman-Ostrosky Talia

Abstract excerpt

PURPOSE: Astrocytomas are a type of malignant brain tumor with an unfavorable clinical course. The impact of AGT and MGMT somatic variants in the prognosis of astrocytoma is unknown, and it is controversial for TP53. Moreover, there is a lack of knowledge regarding the molecular characteristics of astrocytomas in Mexican patients. METHODS: We studied 48 Mexican patients, men and women, with astrocytoma (discovery...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36525166
DOI: 10.1007/s11060-022-04214-1

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