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Article

Adaptive evolution among cytoplasmic piRNA proteins leads to decreased genomic auto-immunity.

PLoS genetics - 1 Jun 2020

Wang Luyang, Barbash Daniel A, Kelleher Erin S

Abstract excerpt

In metazoan germlines, the piRNA pathway acts as a genomic immune system, employing small RNA-mediated silencing to defend host DNA from the harmful effects of transposable elements (TEs). Expression of genomic TEs is proposed to initiate self regulation by increasing the production of repressive piRNAs, thereby "adapting" piRNA-mediated control to the most active TE families. Surprisingly, however, piRNA pathway...

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Identifiers

PMID: 32525870
DOI: 10.1371/journal.pgen.1008861
PMCID: PMC7310878

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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