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Article

Adaptive Evolution Targets a piRNA Precursor Transcription Network.

Cell reports - 25 Feb 2020

Parhad Swapnil S, Yu Tianxiong, Zhang Gen, Rice Nicholas P, Weng Zhiping, Theurkauf William E

Abstract excerpt

In Drosophila, transposon-silencing piRNAs are derived from heterochromatic clusters and a subset of euchromatic transposon insertions, which are bound by the Rhino-Deadlock-Cutoff complex. The HP1 homolog Rhino binds to Deadlock, which recruits TRF2 to promote non-canonical transcription from both genomic strands. Cuff function is less well understood, but this Rai1 homolog shows hallmarks of adaptive evolution,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32101744
DOI: 10.1016/j.celrep.2020.01.109
PMCID: PMC7061269

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