Article
Restriction of essential amino acids dictates the systemic metabolic response to dietary protein dilution.
Nature communications - 9 Jun 2020
Yap Yann W, Rusu Patricia M, Chan Andrea Y, Fam Barbara C, Jungmann Andreas, Solon-Biet Samantha M, Barlow Christopher K, Creek Darren J, Huang Cheng, Schittenhelm Ralf B, Morgan Bruce, Schmoll Dieter, Kiens Bente, Piper Matthew D W, Heikenwälder Mathias, Simpson Stephen J, Bröer Stefan, Andrikopoulos Sofianos, Müller Oliver J, Rose Adam J
Abstract excerpt
Dietary protein dilution (DPD) promotes metabolic-remodelling and -health but the precise nutritional components driving this response remain elusive. Here, by mimicking amino acid (AA) supply from a casein-based diet, we demonstrate that restriction of dietary essential AA (EAA), but not non-EAA, drives the systemic metabolic response to total AA deprivation; independent from dietary carbohydrate supply....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.