Article
Molecular alterations in the extracellular matrix in the brains of newborns with congenital Zika syndrome.
Science signaling - 9 Jun 2020
Aguiar Renato S, Pohl Fabio, Morais Guilherme L, Nogueira Fabio C S, Carvalho Joseane B, Guida Letícia, Arge Luis W P, Melo Adriana, Moreira Maria E L, Cunha Daniela P, Gomes Leonardo, Portari Elyzabeth A, Velasquez Erika, Melani Rafael D, Pezzuto Paula, de Castro Fernanda L, Geddes Victor E V, Gerber Alexandra L, Azevedo Girlene S, Schamber-Reis Bruno L, Gonçalves Alessandro L, Junqueira-de-Azevedo Inácio, Nishiyama Milton Y, Ho Paulo L, Schanoski Alessandra S, Schuch Viviane, Tanuri Amilcar, Chimelli Leila, Vasconcelos Zilton F M, Domont Gilberto B, Vasconcelos Ana T R, Nakaya Helder I
Abstract excerpt
Zika virus (ZIKV) infection during pregnancy can cause a set of severe abnormalities in the fetus known as congenital Zika syndrome (CZS). Experiments with animal models and in vitro systems have substantially contributed to our understanding of the pathophysiology of ZIKV infection. Here, to investigate the molecular basis of CZS in humans, we used a systems biology approach to integrate transcriptomic,...
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