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Disruption of myelin structure and oligodendrocyte maturation in a macaque model of congenital Zika infection

18 Jun 2024

Abstract excerpt

Zika virus (ZikV) infection during pregnancy can cause congenital Zika syndrome (CZS) and neurodevelopmental delay in infants, of which the pathogenesis remains poorly understood. We utilize an established female pigtail macaque maternal-to-fetal ZikV infection/exposure model to study fetal brain pathophysiology of CZS manifesting from ZikV exposure in utero. We find prenatal ZikV exposure leads to profound...

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PMID: 38890352
DOI: 10.1038/s41467-024-49524-2

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