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Article

Genetic control of Group 3 (K96) capsule synthesis and complement resistance in extraintestinal pathogenic Escherichia coli.

mSphere - 28 Jul 2026

David Prince Rachael J, Bogati Rajesh, Lytle Titan, Collado Silva Andres, LeBaron Rachael A, Sorge Tiana, Olson Michael A, Wilson Eric, Erickson David L

Abstract excerpt

Extraintestinal pathogenic Escherichia coli (ExPEC) frequently produce Group 2 or 3 capsules that enhance virulence, yet genetic regulation and specific roles of Group 3 capsules remain poorly understood. Here, we demonstrate that the K96 Group 3 capsule in ExPEC strain M12 confers resistance to human serum complement. Using genetic screens, we identified phase-variable mutations in kpsC and essential roles for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42429621
DOI: 10.1128/msphere.00237-26
PMCID: PMC13410964

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