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Article

Polygenic interactions with adiposity rebound in the prediction of thelarche.

Pediatric research - 1 Mar 2021

Fang Jiao, Gong Chun, Su Puyu, Wan Yuhui, Zhang Zhihua, Tao Fangbiao, Sun Ying

Abstract excerpt

BACKGROUND: The earliest onset of puberty had shifted downward, which may be due to the role of early growth and development factors in childhood. METHODS: All of 1575 Kindergarten Two (K2) children from Anhui province, China were followed up to elementary school. Girls (n = 342) with available data on AR and breast development were included for this analysis. Polygenic risk score (PRS) was computed based on 17...

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PMID: 32512580
DOI: 10.1038/s41390-020-1001-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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