Article
Genetic factors of idiopathic central precocious puberty and their polygenic risk in early puberty.
European journal of endocrinology - 27 Aug 2021
Lin Wei-De, Cheng Chi-Fung, Wang Chung-Hsing, Liang Wen-Miin, Chen Chien-Hsiun, Hsieh Ai-Ru, Chiu Mu-Lin, Lin Ting-Hsu, Liao Chiu-Chu, Huang Shao-Mei, Tsai Chang-Hai, Chang Cherry Yin-Yi, Lin Ying-Ju, Tsai Fuu-Jen
Abstract excerpt
OBJECTIVE,: To investigate the genetic characteristics of idiopathic central precocious puberty (ICPP) and validate its polygenic risk for early puberty. DESIGN AND METHODS: A bootstrap subsampling and genome-wide association study were performed on Taiwanese Han Chinese girls comprising 321 ICPP patients and 148 controls. Using previous GWAS data on pubertal timing, a replication study was performed. A...
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