Article
Testisin/Prss21 deficiency causes increased vascular permeability and a hemorrhagic phenotype during luteal angiogenesis.
PloS one - 1 Jan 2020
Peroutka Raymond J, Buzza Marguerite S, Mukhopadhyay Subhradip, Johnson Tierra A, Driesbaugh Kathryn H, Antalis Toni M
Abstract excerpt
Testisin (encoded by PRSS21) is a membrane anchored serine protease, which is tethered to the cell surface via a glycosylphosphatidylinositol (GPI)-anchor. While testisin is found in abundance in spermatozoa, it is also expressed in microvascular endothelial cells where its function is unknown. Here we identify testisin as a novel regulator of physiological hormone-induced angiogenesis and microvascular...
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