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Article

Germ Cell Migration Across Sertoli Cell Tight Junctions

21 Sept 2012

Abstract excerpt

The blood-testis barrier includes strands of tight junctions between somatic Sertoli cells that restricts solutes from crossing the paracellular space, creating a microenvironment within seminiferous tubules and providing immune privilege to meiotic and postmeiotic cells. Large cysts of germ cells transit the Sertoli cell tight junctions (SCTJs) without compromising their integrity. We used confocal microscopy to...

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PMID: 22997133
DOI: 10.1126/science.1219969

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