Article
Lack of association between LGMN and Alzheimer's disease in the Southern Han Chinese population.
The European journal of neuroscience - 1 Oct 2020
Zhang Xinyue, Jiao Bin, Weng Ling, Zhou Yafang, Guo Lina, Wang Xin, Zhou Lu, Liu Xixi, Xiao Xuewen, Liu Hui, Zhu Xiangyu, Li Chenping, Zhu Yuan, Yang Qijie, Lin Zhuojie, Jiang Yaling, Wen Yafei, Zhou Hui, Shen Lu, Liao Xinxin
Abstract excerpt
Recently, functional studies have demonstrated that legumain (LGMN) cleaves both amyloid β-protein precursor and tau, promoting senile plaques and formation of neurofibrillary tangles, which may play a crucial role in the pathogenesis of Alzheimer's disease (AD). However, the genetic role of LGMN in AD has not been clearly elucidated. Here, we used Sanger sequencing to investigate the single independent...
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