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Article

The P86L common allele of CALHM1 does not influence risk for Alzheimer disease in Japanese cohorts.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Mar 2010

Inoue Ken, Tanaka Noriko, Yamashita Fumio, Sawano Yoshie, Asada Takashi, Goto Yu-Ichi

Abstract excerpt

A common P86L variant in CALHM1 was recently identified to increase susceptibility to Alzheimer disease (AD) in individuals of European-descent. To determine whether or not this association is also valid in a different ethnic population, we directly sequenced three nearby SNPs including P86L in more than 2,500 Japanese AD case-control samples. We found no association between CALHM1 P86L polymorphism and AD risk...

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Source

Identifiers

PMID: 19655363
DOI: 10.1002/ajmg.b.31014

Genes

CALHM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The P86L common allele of CALHM1 does not influence risk for Alzheimer disease in Japanese cohorts.PMID 19655363Read ↗

Lack of association between CALHM1 p.P86L variation and Alzheimer's disease in the Han Chinese population.Semantic proximity Read ↗

CALHM1 variant is not associated with Alzheimer's disease among Asians.Semantic proximity Read ↗

CALHM1 P86L polymorphism does not alter amyloid-beta or tau in cerebrospinal fluid.Semantic proximity Read ↗

Genetic association between CALHM1, 2, and 3 polymorphisms and Alzheimer's disease in a Japanese population.Semantic proximity Read ↗

No association between CALHM1 variation and risk of Alzheimer disease.Semantic proximity Read ↗

Lack of implication for CALHM1 P86L common variation in Italian patients with early and late onset Alzheimer's disease.Semantic proximity Read ↗

CALHM1 P86L polymorphism is associated with late-onset Alzheimer's disease in a recessive model.Semantic proximity Read ↗

No association between CALHM1 polymorphism and Alzheimer's disease risk in a Hungarian population.Semantic proximity Read ↗

CALHM1 P86L polymorphism modulates CSF Aβ levels in cognitively healthy individuals at risk for Alzheimer's disease.Semantic proximity Read ↗

Calcium homeostasis modulator 1 gene P86L polymorphism and the risk for alzheimer's disease: A meta-analysis.Semantic proximity Read ↗

No Association between CALHM1 and Alzheimer's Disease RiskSemantic proximity Read ↗

No association between CALHM1 and risk for Alzheimer dementia in a Belgian population.Semantic proximity Read ↗

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