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Article

Mutational variant allele frequency profile as a biomarker of response to immune checkpoint blockade in non-small cell lung Cancer.

Journal of translational medicine - 18 Jun 2024

Gao Ruyun, Lou Ning, Li Lin, Xie Tongji, Xing Puyuan, Tang Le, Yao Jiarui, Han Xiaohong, Shi Yuankai

Abstract excerpt

INTRODUCTION: Identifying new biomarkers for predicting immune checkpoint inhibitors (ICIs) response in non-small cell lung cancer (NSCLC) is crucial. We aimed to assess the variant allele frequency (VAF)-related profile as a novel biomarker for NSCLC personalized therapy. METHODS: We utilized genomic data of 915 NSCLC patients via cBioPortal and a local cohort of 23 patients for model construction and mutational...

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Identifiers

PMID: 38890738
DOI: 10.1186/s12967-024-05400-7
PMCID: PMC11184775

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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