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Article

Homozygous Mutations in BTG4 Cause Zygotic Cleavage Failure and Female Infertility.

American journal of human genetics - 2 Jul 2020

Zheng Wei, Zhou Zhou, Sha Qianqian, Niu Xiangli, Sun Xiaoxi, Shi Juanzi, Zhao Lei, Zhang Shuoping, Dai Jing, Cai Sufen, Meng Fei, Hu Liang, Gong Fei, Li Xiaoran, Fu Jing, Shi Rong, Lu Guangxiu, Chen Biaobang, Fan Hengyu, Wang Lei, Lin Ge, Sang Qing

Abstract excerpt

Zygotic cleavage failure (ZCF) is a unique early embryonic phenotype resulting in female infertility and recurrent failure of in vitro fertilization (IVF) and/or intracytoplasmic sperm injection (ICSI). With this phenotype, morphologically normal oocytes can be retrieved and successfully fertilized, but they fail to undergo cleavage. Until now, whether this phenotype has a Mendelian inheritance pattern and which...

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Identifiers

PMID: 32502391
DOI: 10.1016/j.ajhg.2020.05.010
PMCID: PMC7332666

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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