Secondary analysis of case-control association studies: Insights on weighting-based inference motivate a new specification test.

Abstract excerpt

Case-control sampling is frequently used in genetic association studies to examine the relationship between disease and genetic exposures. Such designs usually collect extensive information on phenotypes beyond the primary disease, whose associations with the genetic exposures are also of great interest. Because the cases are over-sampled, appropriate analysis of secondary phenotypes should take into account this...

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