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Article

Robust estimation for secondary trait association in case-control genetic studies.

American journal of epidemiology - 15 May 2014

Tapsoba Jean de Dieu, Kooperberg Charles, Reiner Alexander, Wang Ching-Yun, Dai James Y

Abstract excerpt

Secondary trait genetic association provides insight into the genetic architecture of disease etiology but requires caution in estimation. Ignoring case-control sampling may introduce bias into secondary trait association. In this paper, we compare the efficiency and robustness of various inverse probability weighted (IPW) estimators and maximum likelihood (ML) estimators. ML methods have been proposed but...

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PMID: 24723002
DOI: 10.1093/aje/kwu039
PMCID: PMC4010189

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