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Article

Overcoming bortezomib resistance in multiple myeloma

1 Aug 2014

Abstract excerpt

The introduction of the proteasome inhibitor bortezomib in 2003 significantly improved treatment of the B-cell malignancy MM (multiple myeloma). Relapse following bortezomib therapy is inevitable, however, and MM remains an incurable disease. In the present mini-review, we explore the mechanisms by which bortezomib resistance occurs in MM, including inherent and acquired mutation, and inducible pro-survival...

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PMID: 25109961
DOI: 10.1042/bst20140126

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