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Polymorphisms of IRAK1 Gene on X Chromosome Is Associated with Hashimoto Thyroiditis in Korean Children.

Endocrinology - 1 Aug 2020

Shin Hye-Ri, Cho Won Kyoung, Baek In-Cheol, Lee Na Yeong, Lee Yoon Ji, Kim Seul Ki, Ahn Moon Bae, Suh Byung-Kyu, Kim Tai-Gyu

Abstract excerpt

Autoimmune thyroid disease (AITD) is predominant in females and has been focused on the sexual diploid in immune response. The IL-1 receptor-associated kinase 1 (IRAK1) gene on the X chromosome was recently suggested as strong autoimmune disease-susceptible loci, second to the major histocompatibility complex region. We investigated the frequency of IRAK1 single-nucleotide polymorphisms (SNPs) in children with...

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PMID: 32498091
DOI: 10.1210/endocr/bqaa088

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