Poor Immunogenicity, Not Vaccine Strain Egg Adaptation, May Explain the Low H3N2 Influenza Vaccine Effectiveness in 2012-2013.

doi:10.1093/cid/ciy097

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Article

Poor Immunogenicity, Not Vaccine Strain Egg Adaptation, May Explain the Low H3N2 Influenza Vaccine Effectiveness in 2012-2013.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 18 Jul 2018

Cobey Sarah, Gouma Sigrid, Parkhouse Kaela, Chambers Benjamin S, Ertl Hildegund C, Schmader Kenneth E, Halpin Rebecca A, Lin Xudong, Stockwell Timothy B, Das Suman R, Landon Emily, Tesic Vera, Youngster Ilan, Pinsky Benjamin A, Wentworth David E, Hensley Scott E, Grad Yonatan H

Abstract excerpt

Background: Influenza vaccination aims to prevent infection by influenza virus and reduce associated morbidity and mortality; however, vaccine effectiveness (VE) can be modest, especially for subtype A(H3N2). Low VE has been attributed to mismatches between the vaccine and circulating influenza strains and to the vaccine's elicitation of protective immunity in only a subset of the population. The low H3N2 VE in...

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PMID: 29471464
DOI: 10.1093/cid/ciy097
PMCID: PMC6051447

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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