Article
Low 2012-13 influenza vaccine effectiveness associated with mutation in the egg-adapted H3N2 vaccine strain not antigenic drift in circulating viruses.
PloS one - 1 Jan 2014
Skowronski Danuta M, Janjua Naveed Z, De Serres Gaston, Sabaiduc Suzana, Eshaghi Alireza, Dickinson James A, Fonseca Kevin, Winter Anne-Luise, Gubbay Jonathan B, Krajden Mel, Petric Martin, Charest Hugues, Bastien Nathalie, Kwindt Trijntje L, Mahmud Salaheddin M, Van Caeseele Paul, Li Yan
Abstract excerpt
BACKGROUND: Influenza vaccine effectiveness (VE) is generally interpreted in the context of vaccine match/mismatch to circulating strains with evolutionary drift in the latter invoked to explain reduced protection. During the 2012-13 season, however, detailed genotypic and phenotypic characterization shows that low VE was instead related to mutations in the egg-adapted H3N2 vaccine strain rather than antigenic...
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