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Article

Epigenetic regulation in opioid induced hyperalgesia

1 Aug 2023

Abstract excerpt

About 25 million American adults experience pain daily and one of the most commonly prescribed drugs to treat pain are opioids. Prolonged opioid usage and dose escalations can cause a paradoxical response where patients experience enhanced pain sensitivity. This opioid induced hyperalgesia (OIH) is a major hurdle when treating pain in the clinic because its underlying mechanisms are still not fully understood....

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PMID: 38099284
DOI: 10.1016/j.ynpai.2023.100146

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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