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Article

SHP2 mutations induce precocious gliogenesis of Noonan syndrome-derived iPSCs during neural development in vitro.

Stem cell research & therapy - 3 Jun 2020

Ju Younghee, Park Jun Sung, Kim Daejeong, Kim Bumsoo, Lee Jeong Ho, Nam Yoonkey, Yoo Han-Wook, Lee Beom Hee, Han Yong-Mahn

Abstract excerpt

BACKGROUND: Noonan syndrome (NS) is a developmental disorder caused by mutations of Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2). Although NS patients have diverse neurological manifestations, the mechanisms underlying the involvement of SHP2 mutations in neurological dysfunction remain elusive. METHODS: Induced pluripotent stem cells generated from dermal fibroblasts of three...

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Identifiers

PMID: 32493428
DOI: 10.1186/s13287-020-01709-4
PMCID: PMC7268229

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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