Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human Schlafen 5 regulates reversible epithelial and mesenchymal transitions in breast cancer by suppression of ZEB1 transcription

2 Jun 2020

Abstract excerpt

BACKGROUND: Human Schlafen 5 (SLFN5) has been reported to inhibit or promote cell invasion in tumours depending on their origin. However, its role in breast cancer (BRCA) is undetermined. METHODS: Differential expression analyses using The Cancer Genome Atlas (TCGA) data, clinical samples and cell lines were performed. Lentiviral knockdown and overexpression experiments were performed to detect changes in cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Axon Guidance and Neuronal Signaling
Share to Parkinson's Disease Mechanisms and Treatments
Share to PARP inhibition in cancer therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32488136
DOI: 10.1038/s41416-020-0873-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human Schlafen 5 regulates reversible epithelial and mesenchymal transitions in breast cancer by suppression of ZEB1 transcriptionPMID 32488136Read ↗

Structural, molecular, and functional insights into Schlafen proteinsSemantic proximity Read ↗

Genome–wide binding of transcription factor ZEB1 in triple‐negative breast cancer cellsSemantic proximity Read ↗

ZEB2 upregulates integrin α5 expression through cooperation with Sp1 to induce invasion during epithelial–mesenchymal transition of human cancer cellsSemantic proximity Read ↗

Functional Hierarchy and Cooperation of EMT Master Transcription Factors in Breast Cancer MetastasisSemantic proximity Read ↗

HMGN5 escorts oncogenic STAT3 signaling by regulating chromatin landscape in tumorigenesis of breast cancerSemantic proximity Read ↗

FXYD5/Dysadherin, a Biomarker of Endometrial Cancer Myometrial Invasion and Aggressiveness: Its Relationship With TGF-β1 and NF-κB PathwaysSemantic proximity Read ↗

Human SLFN5 is a transcriptional co-repressor of STAT1-mediated interferon responses and promotes the malignant phenotype in glioblastomaSemantic proximity Read ↗

FZD5 contributes to TNBC proliferation, DNA damage repair and stemness.Semantic proximity Read ↗

Epithelial–Mesenchymal Transition and Tumor Suppression Are Controlled by a Reciprocal Feedback Loop between ZEB1 and Grainyhead-like-2Semantic proximity Read ↗

ZEB2–Sp1 cooperation induces invasion by upregulating cadherin-11 and integrin α5 expressionSemantic proximity Read ↗

Molecular Mechanisms of Epithelial to Mesenchymal Transition Regulated by ERK5 Signaling.Semantic proximity Read ↗

Pleiotropic Roles for ZEB1 in CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.