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Article

FZD5 contributes to TNBC proliferation, DNA damage repair and stemness.

Cell death & disease - 12 Dec 2020

Sun Yu, Wang Zhuo, Na Lei, Dong Dan, Wang Wei, Zhao Chenghai

Abstract excerpt

Chemotherapy currently remains the standard treatment for triple-negative breast cancer (TNBC). However, TNBC frequently develop chemoresistance, which is responsible for cancer recurrence and distal metastasis. Both DNA damage repair and stemness are related to chemoresistance. FZD5, a member in Frizzled family, was identified to be preferentially expressed in TNBC, and associated with unfavorable prognosis....

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Identifiers

PMID: 33311446
DOI: 10.1038/s41419-020-03282-3
PMCID: PMC7733599

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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