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Article

ZEB2–Sp1 cooperation induces invasion by upregulating cadherin-11 and integrin α5 expression

15 Oct 2013

Abstract excerpt

Epithelial-mesenchymal transition (EMT) is a process implicated in invasion and metastasis. EMT is characterized by repression of epithelial markers and induction of mesenchymal markers. ZEB2 is a transcriptional repressor of E-cadherin, leading to EMT. Previously, we have shown that ZEB2 directly upregulates integrin α5 transcription by cooperating with the transcription factor Sp1. In this study, we...

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PMID: 24130169
DOI: 10.1093/carcin/bgt340

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