Article
Expanding the substrate scope of phenylalanine ammonia-lyase from Petroselinum crispum towards styrylalanines.
Organic & biomolecular chemistry - 3 May 2017
Bencze László Csaba, Filip Alina, Bánóczi Gergely, Toşa Monica Ioana, Irimie Florin Dan, Gellért Ákos, Poppe László, Paizs Csaba
Abstract excerpt
This study focuses on the expansion of the substrate scope of phenylalanine ammonia-lyase from Petroselinum crispum (PcPAL) towards the l-enantiomers of racemic styrylalanines rac-1a-d - which are less studied and synthetically challenging unnatural amino acids - by reshaping the aromatic binding pocket of the active site of PcPAL by point mutations. Ammonia elimination from l-styrylalanine (l-1a) catalyzed by...
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