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The effect of surgical trauma on circulating free DNA levels in cancer patients—implications for studies of circulating tumor DNA

29 May 2020

Abstract excerpt

Detection of circulating tumor DNA (ctDNA) post-treatment is an emerging marker of residual disease. ctDNA constitutes only a minor fraction of the cell-free DNA (cfDNA) circulating in cancer patients, complicating ctDNA detection. This is exacerbated by trauma-induced cfDNA. To guide optimal blood sample timing, we investigated the duration and magnitude of surgical trauma-induced cfDNA in patients with...

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PMID: 32471011
DOI: 10.1002/1878-0261.12729

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