Article
Twist1 accelerates tumour vasculogenic mimicry by inhibiting Claudin15 expression in triple-negative breast cancer.
Journal of cellular and molecular medicine - 1 Jul 2020
Zhang Danfang, Sun Baocun, Zhao Xiulan, Sun Huizhi, An Jindan, Lin Xian, Zhu Dongwang, Zhao Xueming, Wang Xudong, Liu Fang, Zhang Yanhui, Liu Jiameng, Gu Qiang, Dong Xueyi, Qiu Zhiqiang, Liu Zhiyong, Qi Hong, Che Na, Li Jing, Cheng Runfen, Zheng Xu
Abstract excerpt
The up-regulation of EMT regulator Twist1 has been implicated in vasculogenic mimicry (VM) formation in human triple-negative breast cancer (TNBC). Twist1 targets the Claudin15 promoter in hepatocellular carcinoma cells. Claudin family members are related with TNBC. However, the relationship between Claudin15 and VM formation is not clear. In this study, we first found that Claudin15 expression was frequently...
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