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Article

Genome-defined African ancestry is associated with distinct mutations and worse survival in patients with diffuse large B-cell lymphoma.

Cancer - 1 Aug 2020

Lee Michelle J, Koff Jean L, Switchenko Jeffrey M, Jhaney C Ileen, Harkins R Andrew, Patel Sharvil P, Dave Sandeep S, Flowers Christopher R

Abstract excerpt

BACKGROUND: Significant racial differences have been observed in the incidence and clinical outcomes of diffuse large B-cell lymphoma (DLBCL) in the United States, but to the authors' knowledge it remains unclear whether genomic differences contribute to these disparities. METHODS: To understand the influences of genetic ancestry on tumor genomic alterations, the authors estimated the genetic ancestry of 1001...

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Identifiers

PMID: 32469082
DOI: 10.1002/cncr.32866
PMCID: PMC7494053

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