Article
High resolution melting profiles (HRMPs) obtained by magnetic induction cycler (MIC) have been used to monitor the BRCA2 status highlighted by next generation tumor sequencing (NGTS): a combined approach in a diagnostic environment.
Molecular biology reports - 1 Jun 2020
Mazzuccato Giorgia, De Bonis Maria, Carboni Vittoria, Marchetti Claudia, Urbani Andrea, Scambia Giovanni, Capoluongo Ettore, Fagotti Anna, Minucci Angelo
Abstract excerpt
Resistance can be the result of secondary tissue variants (STVs), which restore the open reading frame of the germline BRCA allele, producing functional BRCA protein in germline BRCA1/2 (BRCA) pathogenic variant (PV) carriers, treated with platinum-based chemotherapy or poly-(ADP-ribose) polymerase inhibitors (PARP-1). We reported recently a BRCA2 mutant high grade serous ovarian cancer (HGSOC) patient with...
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