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Article

Evolution of generalism under Muller's ratchet.

Trends in parasitology - 1 Aug 2026

van Oosterhout Cock

Abstract excerpt

Host-range expansion in parasites is usually framed as an adaptive response to heterogeneous environments and trade-offs. In this opinion article, I propose Ratchet-Driven Generalism (RDG): in some parasites, broad host range may instead arise non-adaptively after the loss of sexual recombination. Under Muller's ratchet, deleterious mutations accumulate in asexual or rarely recombining lineages. Over time,...

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Identifiers

PMID: 42362460
DOI: 10.1016/j.pt.2026.06.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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