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Potential Therapeutic Targeting of Coronavirus Spike Glycoprotein Priming

22 May 2020

Abstract excerpt

Processing of certain viral proteins and bacterial toxins by host serine proteases is a frequent and critical step in virulence. The coronavirus spike glycoprotein contains three (S1, S2, and S2') cleavage sites that are processed by human host proteases. The exact nature of these cleavage sites, and their respective processing proteases, can determine whether the virus can cross species and the level of...

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PMID: 32455942
DOI: 10.3390/molecules25102424

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