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Article

circCUL2 induces an inflammatory CAF phenotype in pancreatic ductal adenocarcinoma via the activation of the MyD88-dependent NF-κB signaling pathway.

Journal of experimental & clinical cancer research : CR - 21 Feb 2022

Zheng Shangyou, Hu Chonghui, Lin Hongcao, Li Guolin, Xia Renpeng, Zhang Xiang, Su Dan, Li Zhihua, Zhou Quanbo, Chen Rufu

Abstract excerpt

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is characterized by clusters of cancer cells surrounded by a dense desmoplastic stroma. However, little is known about stromal cell heterogeneity in the pancreatic tumor microenvironment. METHODS: We conducted circRNA profiling in primary fibroblasts by high-throughput sequencing and detected circCUL2 levels in PDAC tissues by qRT-PCR. We subsequently...

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Identifiers

PMID: 35189958
DOI: 10.1186/s13046-021-02237-6
PMCID: PMC8862589

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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