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Article

Allosteric regulation of mammalian Na+/I- symporter activity by perchlorate.

Nature structural & molecular biology - 1 Jun 2020

Llorente-Esteban Alejandro, Manville Rían W, Reyna-Neyra Andrea, Abbott Geoffrey W, Amzel L Mario, Carrasco Nancy

Abstract excerpt

The Na+/I- symporter (NIS), the plasma membrane protein that actively transports I- (stoichiometry 2Na+:1I-) in thyroid physiology and radioiodide-based thyroid cancer treatment, also transports the environmental pollutant perchlorate (stoichiometry 1Na+:1ClO4-), which competes with I- for transport. Until now, the mechanism by which NIS transports different anion substrates with different stoichiometries has...

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Identifiers

PMID: 32451489
DOI: 10.1038/s41594-020-0417-5
PMCID: PMC10158964

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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