A Cell-Based MAPK Reporter Assay Reveals Synergistic MAPK Pathway Activity Suppression by MAPK Inhibitor Combination in BRAF-Driven Pediatric Low-Grade Glioma Cells.

doi:10.1158/1535-7163.MCT-19-1021

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

A Cell-Based MAPK Reporter Assay Reveals Synergistic MAPK Pathway Activity Suppression by MAPK Inhibitor Combination in BRAF-Driven Pediatric Low-Grade Glioma Cells.

Molecular cancer therapeutics - 1 Aug 2020

Usta Diren, Sigaud Romain, Buhl Juliane L, Selt Florian, Marquardt Viktoria, Pauck David, Jansen Jennifer, Pusch Stefan, Ecker Jonas, Hielscher Thomas, Vollmer Johanna, Sommerkamp Alexander C, Rubner Tobias, Hargrave Darren, van Tilburg Cornelis M, Pfister Stefan M, Jones David T W, Remke Marc, Brummer Tilman, Witt Olaf, Milde Till

Abstract excerpt

Pilocytic astrocytomas as well as other pediatric low-grade gliomas (pLGG) exhibit genetic events leading to aberrant activation of the MAPK pathway. The most common alterations are KIAA1549:BRAF fusions and BRAFV600E and NF1 mutations. Novel drugs targeting the MAPK pathway (MAPKi) are prime candidates for the treatment of these single-pathway diseases. We aimed to develop an assay suitable for preclinical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Reporter

Share to Glioma

Share to Mitogen-Activated Protein Kinases

Share to Neoplasm Grading

Share to Protein Kinase Inhibitors

Share to Proto-Oncogene Proteins B-raf

Share to Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 32451331
DOI: 10.1158/1535-7163.MCT-19-1021

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Cell-Based MAPK Reporter Assay Reveals Synergistic MAPK Pathway Activity Suppression by MAPK Inhibitor Combination in BRAF-Driven Pediatric Low-Grade Glioma Cells.PMID 32451331Read ↗

The first-in-class ERK inhibitor ulixertinib shows promising activity in mitogen-activated protein kinase (MAPK)-driven pediatric low-grade glioma models.Semantic proximity Read ↗

BRAF and MEK Targeted Therapies in Pediatric Central Nervous System TumorsSemantic proximity Read ↗

Optimizing preclinical pediatric low-grade glioma models for meaningful clinical translation.Semantic proximity Read ↗

Multi-omics dissection of MAPK-driven senescence unveils therapeutic vulnerabilities in KIAA1549::BRAF-fusion pediatric low-grade glioma modelsSemantic proximity Read ↗

MAPK pathway activation in pilocytic astrocytomaSemantic proximity Read ↗

MAPK inhibitor sensitivity scores predict sensitivity driven by the immune infiltration in pediatric low-grade gliomasSemantic proximity Read ↗

Rebound growth of BRAF mutant pediatric glioma cells after MAPKi withdrawal is associated with MAPK reactivation and secretion of microglia-recruiting cytokines.Semantic proximity Read ↗

An activated mutant BRAF kinase domain is sufficient to induce pilocytic astrocytoma in mice.Semantic proximity Read ↗

MAPK4 predicts poor prognosis and facilitates the proliferation and migration of glioma through the AKT / mTOR pathwaySemantic proximity Read ↗

Overcoming resistance to single-agent therapy for oncogenic BRAF gene fusions via combinatorial targeting of MAPK and PI3K/mTOR signaling pathwaysSemantic proximity Read ↗

Genetic Predisposition to Glioma Mediated by a MAPKAP1 Enhancer Variant.Semantic proximity Read ↗

CRAF gene fusions in pediatric low-grade gliomas define a distinct drug response based on dimerization profilesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.