Article
An activated mutant BRAF kinase domain is sufficient to induce pilocytic astrocytoma in mice.
The Journal of clinical investigation - 1 Apr 2011
Gronych Jan, Korshunov Andrey, Bageritz Josephine, Milde Till, Jugold Manfred, Hambardzumyan Dolores, Remke Marc, Hartmann Christian, Witt Hendrik, Jones David T W, Witt Olaf, Heiland Sabine, Bendszus Martin, Holland Eric C, Pfister Stefan, Lichter Peter
Abstract excerpt
Pilocytic astrocytoma (PA) is the most common type of primary brain tumor in children and the second most frequent cancer in childhood. Children with incompletely resected PA represent a clinically challenging patient cohort for whom conventional adjuvant therapies are only moderately effective. This has produced high clinical demand for testing of new molecularly targeted treatments. However, the development of...
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