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Article

GSDM gene polymorphisms regulate the IgE level in asthmatic patients.

PloS one - 1 Jan 2022

Imraish Amer, Abu-Thiab Tuqa, Alhindi Tareq, Zihlif Malek

Abstract excerpt

BACKGROUND: Gasdermin A (GSDMA) and gasdermin B (GSDMB) have been associated with childhood and adult asthma in many populations including the Jordanian population. It is also known that IgE plays a crucial role in various allergic disorders, such elevated levels of total serum IgE were detected in asthma and allergic rhinitis. IgE immunoglobulin is responsible for the release of numerous inflammatory mediators,...

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Identifiers

PMID: 36201519
DOI: 10.1371/journal.pone.0274951
PMCID: PMC9536611

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