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Article

Impact of the gonococcal FC428 penA allele 60.001 on ceftriaxone resistance and biological fitness.

Emerging microbes & infections - 1 Dec 2020

Zhou Ke, Chen Shao-Chun, Yang Fan, van der Veen Stijn, Yin Yue-Ping

Abstract excerpt

Global dissemination of the Neisseria gonorrhoeae ceftriaxone-resistant FC428 clone jeopardizes the currently recommended ceftriaxone-based first-line therapies. Ceftriaxone resistance in the FC428 clone has been associated with the presence of its mosaic penA allele 60.001. Here we investigated the contribution penA allele 60.001 to ceftriaxone resistance and its impact on biological fitness. Gonococcal isolates...

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Source

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Identifiers

PMID: 32438866
DOI: 10.1080/22221751.2020.1773325
PMCID: PMC7448936

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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