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PenA Alleles Associated With Gonococcal Ceftriaxone Resistance in Cambodia, China, and Vietnam.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 8 Jan 2026

van der Veen Stijn, Sun Xia, Ge Haoyu, Chau Tran M, Nhung Pham Hong, Vandelannoote Koen, Delvallez Gauthier, Cheng Sokleaph, Laumen Jolein Gyonne Elise, Adamson Paul C

Abstract excerpt

BACKGROUND: The global dissemination of ceftriaxone-resistant Neisseria gonorrhoeae, primarily associated with mosaic penA alleles, threatens the efficacy of ceftriaxone therapy. While the FC428 clone and its associated penA allele 60.001 are well-documented, data on other emerging resistance-conferring alleles in high-burden regions remain limited. This study characterizes the penA alleles associated with...

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Cambodia
Ceftriaxone
Drug Resistance, Bacterial
Gonorrhea
Microbial Sensitivity Tests

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Multilocus Sequence Typing

Neisseria gonorrhoeae

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Open in PubMed Open full text

Identifiers

PMID: 41504563
DOI: 10.1093/cid/ciaf530
PMCID: PMC12781196

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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