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The role of the L421P mutation in Penicillin-Binding Protein 1 (PBP1) in the evolution of chromosomally mediated penicillin resistance in <i>Neisseria gonorrhoeae</i>

2025-06-29

Abstract excerpt

ponA L421P encodes a mutated variant of penicillin-binding protein 1 (PBP1) and is a key resistance determinant that increases the penicillin MIC (MIC PEN ) above the clinical breakpoint in Neisseria gonorrhoeae . Despite the removal of penicillin from treatment guidelines for gonococcal infections in the 1980s, ponA L421P is present in nearly 50% of current N. gonorrhoeae isolates in the PubMLST database. Bio...

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Literature Corpus work
bb5b80ca-a939-5205-9428-6627f3ff2aeb
DOI
10.1101/2025.06.27.662027
Open publication

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